A study from RCSI University of Medicine and Health Sciences has gained new insights into changes in heart function and blood pressure in the lungs of babies born with Down Syndrome.
Heart and lung conditions are common in babies born with Down Syndrome and can contribute to the requirement for intensive care and longer hospital admissions for babies with Down Syndrome compared to babies without Down Syndrome. The findings of this work will help clinicians to better asses one in 600 babies who are born with Down Syndrome in Ireland every year.
Published in the Journal of the American Society of Echocardiography, the study is the first of its kind to follow babies with Down Syndrome over the first two years of age to investigate heart function and increased blood pressure in the blood vessels in their lungs. Seventy babies with Down Syndrome were followed in this study through collaboration between three neonatal intensive care units in Dublin, Ireland.
This research found that the babies with Down Syndrome have impaired changes in heart function and blood pressure in the lungs over the first two years of age Importantly, there were no differences in heart function between those babies with Down Syndrome who had congenital heart disease compared to those without over the study period. This is a significant finding and indicates that all babies with Down Syndrome should have their heart function and blood pressure in their lungs monitored during childhood.
Until this point, there has been a dearth of evidence to explain why babies with Down Syndrome experience these issues. The results of this study show us that babies with Down Syndrome experience changes in the heart function that leads to increased blood pressure in the lungs.”
Professor Afif EL-Khuffash, Clinical Professor of Paediatrics at RCSI and Consultant Neonatologist, at The Rotunda Hospital
First author on the study, Dr Aisling Smith, a Neonatology Specialist Registrar who carried out the research as part of her PhD at RCSI commented: “This study will help clinicians to better understand the mechanisms causing these problems and highlights the importance of monitoring heart function in babies with Down Syndrome over time.”
Approximately half of babies born with Down Syndrome also have congenital heart disease. In this study, 48 babies with Down Syndrome had congenital heart disease and 22 did not. The results from the babies with Down Syndrome were compared to 60 babies without Down Syndrome (controls). All babies enrolled in the study underwent a heart scan (echocardiogram) to assess heart function at six months, one year and two years of age.
The research was conducted by RCSI in collaboration with the Rotunda, Coombe and National Maternity Hospitals in Dublin; the Department of Paediatric Cardiology, Children’s Health at Crumlin Hospital, Dublin; Department of Paediatrics and Child Health, Trinity College Dublin, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.
The study was funded by the Health Research Board Ireland and the National Children’s Research Centre.
Smith, A., et al. (2022) Serial Assessment of Cardiac Function and Pulmonary Hemodynamics in Infants with Down Syndrome. Journal of the American Society of Echocardiography. doi.org/10.1016/j.echo.2022.07.012.